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In enzymes exhibiting DHAR activity, the first cysteine residue in the G-site motif is known to react with the sulphur atom in disulfide bonds within GSH mixed disulfide bridges and then promotes thiol transfer

But modern supplements use plant-based sources due to safety concerns

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Endogenous oxalate production is thought to be fairly constant, attributing for up to 6080% of total plasma oxalate and urinary oxalate excretion [6, 7]